The van der Laan group contributes state-of-the-art software for Targeted Learning over a wide range of platforms, primarily using the R language and environment for statistical computing but also occasionally in programming languages including Python, Julia, SAS, C++, and Java.
The tlverse software ecosystem is a centralized effort to overhaul the state and availability of Targeted Learning software in R. For a more general (but slightly dated) set of opensource software packages, consider checking out the UC Berkeley Biostatistics Software Community.
The van der Laan Group GitHub organization is accessible on GitHub.
Software contributions are also routinely available on the GitHub profiles of individual students.